Synthesis of 2-hetaryl substituted indoles via palladium-catalysed reductive N-heterocyclisation
β Scribed by S. Tollari; S. Cenini; A. Rossi; G. Palmisano
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 107 KB
- Volume
- 135
- Category
- Article
- ISSN
- 1381-1169
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π SIMILAR VOLUMES
The copper/palladium-promoted heteroannulation of terminal acetylenic compounds in the presence of resin bound ortho-hydroxy aryl iodides is described. The process produces 2-substituted benzofuran derivatives in good yield and high purity.
The complex [PPN][Rh(CO),] is a very efficient catalyst for the conversion of 2-nitrostilbene to 2-phenylindole by reduction by CO followed by cyclisation. The reaction is quite selective (up to 85%) and the only observable by-product is the amine corresponding to the starting material. The addition