A straightforward solid-phase synthesis of 2-aminoimidazolone derivatives is described. The synthesis starts with immobilization of thioureas onto solid support, followed by HBTU/DIEA assisted coupling of Boc-protected amino acids. Upon removal of the Boc group, intramolecular cyclization and simult
Solid-Phase Synthesis of 2-Aminoimidazolones
โ Scribed by Fu, Mengmeng; Fernandez, Monica; Smith, Marie L.; Flygare, John A.
- Book ID
- 118046664
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 117 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1523-7060
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๐ SIMILAR VOLUMES
The synthesis of 2-aminoimidazolinones from resin-bound amino acids is described. Reaction of resinbound amino acids with isothiocyanates followed by treatment of the thioureas with Mukaiyama's reagent aorded the corresponding carbodiimides, which reacted with amines to give 2-aminoimidazolinones in
Solid-phase synthesis of A2-isoxazolines through a 1,3-dipolar cycioaddition of nitrile oxides is described. The aldoxime is oxidized with commercially available bleach to give the corresponding nitrile oxide, which reacts in situ with dipolarophiles to afford A2-isoxazolines in good yields.