A solid-phase synthesis of benzimidazoles, substituted on the aromatic ring by a variety of groups or atoms, is described. Intermediate 3, derived from the acylation of a resin-bound secondary amine with Fmoc-glycine, was elaborated via nucleophilic displacement with substituted o-halonitroarenes to
Solid-phase synthesis of substituted 2-aminomethylbenzimidazoles
โ Scribed by John P Kilburn; Jesper Lau; Raymond C.F Jones
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 109 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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