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Efficient solid-phase synthesis of 2,3-substituted indoles

โœ Scribed by Dean A Wacker; Padmaja Kasireddy

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
65 KB
Volume
43
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The development of the solid-phase version of the modified Madelung indole synthesis is reported. The chemistry was initiated with the reductive amination of Bal resin using an ortho substituted aniline. The resin bound aniline was acylated with a variety of acid chlorides followed by cyclization with base to provide the desired indole after TFA-promoted cleavage from the resin.

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