The development of the solid-phase version of the modified Madelung indole synthesis is reported. The chemistry was initiated with the reductive amination of Bal resin using an ortho substituted aniline. The resin bound aniline was acylated with a variety of acid chlorides followed by cyclization wi
The Solid Phase Synthesis of Tri-Substituted Indoles
โ Scribed by Michael D Collini; John W Ellingboe
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 468 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
Thepslladitmwatafyzed sriidphase synthesis of hi-substituted Moles is deserikd. The synthesis incorporates threeintfepemlemly variable groups andis ideallysuitedfor the preparation of combinatorial libmries.@ 1997Elsevier Science Ltd.
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