✦ LIBER ✦

Solid phase synthesis of highly substituted 2,4-dioxopiperidines

✍ Scribed by Wenying Chai; William V. Murray

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 231 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)01499-9

No coin nor oath required. For personal study only.

✦ Synopsis

A convenient solid phase synthesis of (E)-N-substituted-acetyl-N-(2-methoxycarbonyl-3-(aryl)-prop-2enyl)amino acids and the condensation of their esters to highly substituted 2,4-dioxopiperidines are described.

📜 SIMILAR VOLUMES

Solid phase synthesis of chiral 3-substi

Solid phase synthesis of chiral 3-substituted quinazoline-2,4-diones

✍ Laurent Gouilleux; Jean-Alain Fehrentz; F. Winternitz; Jean Martinez 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 213 KB

Solid-phase synthesis of substituted 2-a

Solid-phase synthesis of substituted 2-aminomethylbenzimidazoles

✍ John P Kilburn; Jesper Lau; Raymond C.F Jones 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 109 KB

Solid-phase synthesis of 2,4-diaminoquin

Solid-phase synthesis of 2,4-diaminoquinazolines

✍ Zhengdong Wu; Jooyoung Kim; Richard M. Soll; Dale S. Dhanoa 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 137 KB 👁 2 views

ChemInform Abstract: Solid-Phase Synthes

ChemInform Abstract: Solid-Phase Synthesis of Chiral 3-Substituted Quinazoline-2,4-diones.

✍ L. GOUILLEUX; J.-A. FEHRENTZ; F. WINTERNITZ; J. MARTINEZ 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 1 views

Solid-Phase Synthesis of Chiral 3-Substituted Quinazoline-2,4-diones. -A series of N-urethane precursors such as (I) or (III) are prepared and subjected to cyclization in the presence of base (DBU, NaOH or NEt3). The desired quinazolines are obtained in good to excellent yield without racemization.

Solid phase parallel synthesis of highly

Solid phase parallel synthesis of highly substituted thiophene derivatives and identification of novel phosphodiesterase-4 (PDE-4) inhibitors

✍ Yongxin Han; André Giroux; Carole Lépine; France Laliberté; Zheng Huang; Hélène 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 826 KB

A versatile protocol for solid phase synthesis of highly substituted thiophene derivatives and their activity against the PDE-4 enzyme are discussed. This protocol employs 3-hydroxymethylthiophene-2-boronic acid (5) as the scaffold and sequential palladium catalyzed cross-coupling reactions as the C

Solid-phase synthesis of substituted ben

Solid-phase synthesis of substituted benzimidazoles

✍ David Tumelty; Matthias K. Schwarz; Kathy Cao; Michael C. Needels 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 216 KB

A solid-phase synthesis of benzimidazoles, substituted on the aromatic ring by a variety of groups or atoms, is described. Intermediate 3, derived from the acylation of a resin-bound secondary amine with Fmoc-glycine, was elaborated via nucleophilic displacement with substituted o-halonitroarenes to