✦ LIBER ✦

Solid phase synthesis of chiral 3-substituted quinazoline-2,4-diones

✍ Scribed by Laurent Gouilleux; Jean-Alain Fehrentz; F. Winternitz; Jean Martinez

Publisher: Elsevier Science
Year: 1996
Tongue: French
Weight: 213 KB
Volume: 37
Category: Article
ISSN: 0040-4039
DOI: 10.1016/0040-4039(96)01541-9

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

ChemInform Abstract: Solid-Phase Synthes

ChemInform Abstract: Solid-Phase Synthesis of Chiral 3-Substituted Quinazoline-2,4-diones.

✍ L. GOUILLEUX; J.-A. FEHRENTZ; F. WINTERNITZ; J. MARTINEZ 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 1 views

Solid-Phase Synthesis of Chiral 3-Substituted Quinazoline-2,4-diones. -A series of N-urethane precursors such as (I) or (III) are prepared and subjected to cyclization in the presence of base (DBU, NaOH or NEt3). The desired quinazolines are obtained in good to excellent yield without racemization.

Solid-phase synthesis of 1,3-dialkyl qui

Solid-phase synthesis of 1,3-dialkyl quinazoline-2,4-diones

✍ Brad O. Buckman; Raju Mohan 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 205 KB

A general and efficient solid phase synt

A general and efficient solid phase synthesis of quinazoline-2,4-diones

✍ Mikhail F Gordeev; Hon C Hui; Eric M Gordon; Dinesh V Patel 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 252 KB

An efficient solid phase synthesis of chiral quinazolinediones is described. Immobilized amino acid based urea derivatives 3 undergo a racemization-free heterocyclization upon gentle heating in presence of tetramethylguanidinc to afford fused pyrimidine-2,4-diones 6, which are smoothly NJ-alkylated

A Facile Synthesis of Substituted 3-Amin

A Facile Synthesis of Substituted 3-Amino-1H-quinazoline-2,4-diones.

✍ Tuan P. Tran; et al. et al. 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 25 KB 👁 2 views

A facile synthesis of substituted 3-amin

A facile synthesis of substituted 3-amino-1H-quinazoline-2,4-diones

✍ Tuan P. Tran; Edmund L. Ellsworth; Brian M. Watson; Joseph P. Sanchez; H. D. Hol 📂 Article 📅 2005 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 124 KB 👁 1 views

A new synthesis of a series of 3-amino-1H-quinazoline-2,4-diones is described. The 1H-quinazoline-2,4dione 10 was made starting with fluorobenzoic acid in three high yielding steps. The key step of this synthesis involved the generation of the dianion of urea 7 and the subsequent intramolecular nucl

Efficient solid-phase synthesis of quina

Efficient solid-phase synthesis of quinazoline-2,4-diones with various substituents on aromatic rings

✍ Tatsuya Okuzumi; Eiji Nakanishi; Takashi Tsuji; Shingo Makino 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 200 KB

We have developed a method for the solid-phase synthesis of quinazoline-2,4-diones with various substituents on the aromatic ring. Although there have been numerous reports of the solid-phase synthesis of quinazoline-2,4-diones, they were not applicable to the synthesis of the quinazoline-2,4-diones