✦ LIBER ✦

Solid-phase synthesis of 2-aminoimidazolinones

✍ Scribed by David H Drewry; Chiara Ghiron

Book ID: 104210771
Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 187 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01194-1

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✦ Synopsis

The synthesis of 2-aminoimidazolinones from resin-bound amino acids is described. Reaction of resinbound amino acids with isothiocyanates followed by treatment of the thioureas with Mukaiyama's reagent aorded the corresponding carbodiimides, which reacted with amines to give 2-aminoimidazolinones in good yield and purity through a cyclization reaction that cleaves the product from the resin.

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