✦ LIBER ✦

Solid-phase synthesis and utilization of side-chain reactive unnatural amino acids

✍ Scribed by Martin J. O'Donnell; Jordi Alsina; William L. Scott

Book ID: 108284762
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 292 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2003.09.119

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Solid-phase synthesis of amino amides an

Solid-phase synthesis of amino amides and peptide amides with unnatural side chains

✍ William L Scott; Francisca Delgado; Karen Lobb; Richard S Pottorf; Martin J O'Do 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 86 KB

Unnatural amino amides and peptide amides can be synthesized, using solid-phase chemistry, from glycine attached directly (or through an intervening peptide sequence) to a Rink resin. The glycine is converted to an activated benzophenone imine derivative, followed by C-alkylation and hydrolysis. Thi

A Solid-Phase Synthetic Route to Unnatur

A Solid-Phase Synthetic Route to Unnatural Amino Acids with Diverse Side-Chain Substitutions

✍ Scott, William L.; O'Donnell, Martin J.; Delgado, Francisca; Alsina, Jordi 📂 Article 📅 2002 🏛 American Chemical Society 🌐 English ⚖ 148 KB

Masked side-chain aldehyde amino acids f

Masked side-chain aldehyde amino acids for solid-phase synthesis and ligation

✍ Jane C. Spetzler; Thomas Hoeg-Jensen 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 92 KB

The masked aldehyde amino acid Fmoc-Hyl(Boc-oxazolidine) 1, has been synthesized from the parent amino acid in five steps (3 pots). The employed protection scheme renders 1 well suited for standard Fmoc-based solid-phase assembly of peptides and similar structures, including TFA-based deprotections.

Solid-phase synthesis of unnatural amino

Solid-phase synthesis of unnatural amino acids using unactivated alkyl halides

✍ Martin J. O'Donnell; Charles W. Lugar; Richard S. Pottorf; Changyou Zhou; Willia 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 249 KB

Conditions were developed for the efficient alkylation of the resin-bound benzophenone imine of glycine with a variety of unreactive alkyl halides. Alkylations were accomplished at room temperature in NMP using the phosphazene-type base, BEMP.

Solid-Phase Synthesis of Amino- and Carb

Solid-Phase Synthesis of Amino- and Carboxyl-Functionalized Unnatural α-Amino Acid Amides

✍ Scott, William L.; Zhou, Ziniu; Martynow, Jacek G.; O’Donnell, Martin J. 📂 Article 📅 2009 🏛 American Chemical Society 🌐 English ⚖ 761 KB

Solid-phase N-glycopeptide synthesis usi

Solid-phase N-glycopeptide synthesis using allyl side-chain protected Fmoc-amino acids

✍ Steven A. Kates; Beatriz G. de la Torre; Ramon Eritja; Fernando Albericio 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 234 KB

A method for the pre aration of ~~~~a~~~~ w&k sektiw a~~~~~a~ ad% copeptides using a three-dimerkonal ortkogonal solid-hase atmched to tk resin is &XX&& rect c~upl~g of ~~0~~s to the car~~~~~~ whr e the peptide IS .P stra!egy