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Solid-phase synthesis of unnatural amino acids using unactivated alkyl halides

✍ Scribed by Martin J. O'Donnell; Charles W. Lugar; Richard S. Pottorf; Changyou Zhou; William L. Scott; Cynthia L. Cwi

Book ID: 104258065
Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 249 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)01762-0

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✦ Synopsis

Conditions were developed for the efficient alkylation of the resin-bound benzophenone imine of glycine with a variety of unreactive alkyl halides. Alkylations were accomplished at room temperature in NMP using the phosphazene-type base, BEMP.

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