Solid phase ring-closing metathesis: Cyclization/cleavage approach towards a seven membered cycloolefin
β Scribed by Jan H. van Maarseveen; Jack A.J. den Hartog; Victor Engelen; Emil Finner; Geb Visser; Chris G. Kruse
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 297 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
A Ru-mediated strategy for the cleavage of organic substrate sizes in moderate to excellent yields. This strategy features the addition of a stoichiometric amount of styrene to the molecules from a solid support via ring-closing metathesis is described. Application of this protocol to solid phase-bo
Ring-closing olefin metathesis using the Grubbs catalyst was applied to the cyclisative release of resin-bound sulfonamides. Flexible linkers apparently facilitated the cyclisation-cleavage, allowing a number of novel cyclic sulfonamides to be prepared in good yields using catalytic amounts of the G
A high-speed solid phase synthesis of Freidinger lactams was accomplished using a novel variant of Fukuyama's amine synthesis and ring closing metathesis-promoted cyclative cleavage as key steps.