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A second generation solid phase approach to Freidinger lactams: Application of Fukuyama's amine synthesis and cyclative release via ring closing metathesis

✍ Scribed by Anthony D. Piscopio; John F. Miller; Kevin Koch


Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
203 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis


A high-speed solid phase synthesis of Freidinger lactams was accomplished using a novel variant of Fukuyama's amine synthesis and ring closing metathesis-promoted cyclative cleavage as key steps.