Ring-Closing Metathesis on Solid Support: Elaboration of a Cyclization/Cleavage Strategy Towards Unsaturated α-Ester-Substituted N-Heterocycles
✍ Scribed by J. J. N. Veerman; Jan H. van Maarseveen; Geb M. Visser; Chris G. Kruse; Hans E. Schoemaker; Henk Hiemstra; Floris P. J. T. Rutjes
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 313 KB
- Volume
- 1998
- Category
- Article
- ISSN
- 1434-193X
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✦ Synopsis
A Ru-mediated strategy for the cleavage of organic substrate sizes in moderate to excellent yields. This strategy features the addition of a stoichiometric amount of styrene to the molecules from a solid support via ring-closing metathesis is described. Application of this protocol to solid phase-bound metathesis mixture, which is shown to increase the yield of the reaction. olefinic amino acid derivatives provides various highly functionalized unsaturated N-heterocycles of different ring-Supporting information for this article is available on the WWW