Solid-phase peptide synthesis using Nα-trityl-amino acids
✍ Scribed by Beatriz G. de la Torre; Miguel A. Marcos; Ramon Eritja; Fernando Albericio
- Book ID
- 110346626
- Publisher
- Springer Netherlands
- Year
- 2001
- Tongue
- English
- Weight
- 90 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1573-3149
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## Abstract Solid‐phase peptide synthesis has many advantages compared with solution peptide synthesis. However, this procedure requires a large amount of organic solvents. Since safe organic solvent waste disposal is an important environmental problem, a technology based on coupling reaction of su
A solid phase synthetic method for amino acids is developed. The N-acetyl-dehydroalanine is quantitatively bound to Wang resin by the Mitsunobu method. Then a Michael addition is achieved on the double bond with different nucleophiles. Non proteinic N-acetyl-ct-amino acids are obtained after cleavag