Solid-Phase One Step Synthesis of 4H-4′-Exomethylene-bis[quinazolin-2-enols]
✍ Scribed by B. A. Ganai; Summon Koul; T. K. Razdan; C. S. Andotra
- Book ID
- 101968172
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 18 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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A versatile method for the solid-phase synthesis of differentially substituted quinazolin-4(3H)-ones has been developed using immobilized arylguanidines. The latter were obtained by treating the amino group of polymer-linked anthranilamide with isothiocyanates followed by coupling with secondary ami
The solid-phase synthesis of 3,4-dihydro-2(1H)-quinazolinones and 3,4-dihydro-1H-quinazolin-2-thiones is described. Starting from Rink resin, acylation with 4-bromomethyl-3-nitrobenzoic acid and amination with primary amines, reduction with tin chloride and cyclization, the desired 3,4-dihydro-2(1H)