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Solid-Phase Combinatorial Synthesis of Peptide−Biphenyl Hybrids as Calpain Inhibitors

✍ Scribed by Montero, Ana; Albericio, Fernando; Royo, Miriam; Herradón, Bernardo


Book ID
125953891
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
39 KB
Volume
8
Category
Article
ISSN
1523-7060

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Solid phase synthesis of peptide vinyl s
✍ Herman S Overkleeft; Pepijn R Bos; Brian G Hekking; Eva J Gordon; Hidde L Ploegh 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 193 KB

The solid phase synthesis of the known proteasome inhibitor ZL 3 VS, using Kenner's safety catch protocol, is described. This methodology has been extended to the synthesis of various novel peptide vinyl sulfone and peptide epoxyketone derivatives.