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Solid phase synthesis of peptide vinyl sulfone and peptide epoxyketone proteasome inhibitors

✍ Scribed by Herman S Overkleeft; Pepijn R Bos; Brian G Hekking; Eva J Gordon; Hidde L Ploegh; Benedikt M Kessler

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
193 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

The solid phase synthesis of the known proteasome inhibitor ZL 3 VS, using Kenner's safety catch protocol, is described. This methodology has been extended to the synthesis of various novel peptide vinyl sulfone and peptide epoxyketone derivatives.

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