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Solid Phase Combinatorial Library of Phosphinic Peptides for Discovery of Matrix Metalloproteinase Inhibitors †

✍ Scribed by Buchardt, Jens; Schiødt, Christine Bruun; Krog-Jensen, Christian; Delaissé, Jean-Marie; Foged, Niels Tækker; Meldal, Morten


Book ID
118740706
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
303 KB
Volume
2
Category
Article
ISSN
1520-4766

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✍ Vincent Dive; Kumari L. Andarawewa; Anne Boulay; Magdalini Matziari; Fabrice Bea 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 290 KB

## Abstract The __in vivo__ disposition and antitumor efficacy of a newly developed phosphinic matrix metalloproteinase inhibitor (RXP03) were examined. RXP03 potently inhibits MMP‐11, MMP‐8 and MMP‐13, but not MMP‐1 and MMP‐7. Twenty‐four hours after i.p. injection into mice, most of the RXP03 was