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Solid-Phase Synthesis of Succinylhydroxamate Peptides: Functionalized Matrix Metalloproteinase Inhibitors

✍ Scribed by Leeuwenburgh, Michiel A.; Geurink, Paul P.; Klein, Theo; Kauffman, Henk F.; van der Marel, Gijs A.; Bischoff, Rainer; Overkleeft, Herman S.


Book ID
126131441
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
135 KB
Volume
8
Category
Article
ISSN
1523-7060

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Solid phase synthesis of peptide vinyl s
✍ Herman S Overkleeft; Pepijn R Bos; Brian G Hekking; Eva J Gordon; Hidde L Ploegh πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 193 KB

The solid phase synthesis of the known proteasome inhibitor ZL 3 VS, using Kenner's safety catch protocol, is described. This methodology has been extended to the synthesis of various novel peptide vinyl sulfone and peptide epoxyketone derivatives.