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Solid-phase amino-zinc-enolate cyclization for the synthesis of 3-substituted prolines

✍ Scribed by Philippe Karoyan; Antonio Triolo; Rossano Nannicini; Danilo Giannotti; Maria Altamura; Gérard Chassaing; Enzo Perrotta

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
214 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

Preparation of 3-substituted prolines was achieved by extension to Solid Phase Organic Synthesis (SPOS) of the amino-zinc-enolate cyclization we have recently described. I Functionalizations of proline at C-3 were considered by nucleophilic substitutions of an iodo derivative obtained on the resin.

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L-Proline Catalyzed Solvent-Free Knoeven
L-Proline Catalyzed Solvent-Free Knoevenagel Condensation for the Synthesis of 3-Substituted Coumarins
✍ Nandkishor. N. KARADE; Sumit V. GAMPAWAR; Sandeep. V. SHINDE; Wamanrao. N. JADHA 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 70 KB 👁 2 views

## Abstract __L__‐Proline was utilized as an efficient organo‐catalyst for the environmentally benign synthesis of 3‐substituted coumarins by the Knoevenagel condensation of substituted 2‐hydroxybenzaldehydes with reactive methylene compounds under solvent free conditions.