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New strategy for the synthesis of 3-substituted prolines

✍ Scribed by Philippe Karoyan; Gérard Chassaing

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
243 KB
Volume
38
Category
Article
ISSN
0040-4039

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Solid-phase amino-zinc-enolate cyclizati
Solid-phase amino-zinc-enolate cyclization for the synthesis of 3-substituted prolines
✍ Philippe Karoyan; Antonio Triolo; Rossano Nannicini; Danilo Giannotti; Maria Alt 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 214 KB

Preparation of 3-substituted prolines was achieved by extension to Solid Phase Organic Synthesis (SPOS) of the amino-zinc-enolate cyclization we have recently described. I Functionalizations of proline at C-3 were considered by nucleophilic substitutions of an iodo derivative obtained on the resin.