Design, synthesis and potential use of 3,9-substituted xanthene handles for Solid Phase Peptide Synthesis
✍ Scribed by Dr. Csaba Somlai; Levente Nyerges; Botond Penke; Péter Hegyes; Wolfgang Voelter
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 455 KB
- Volume
- 336
- Category
- Article
- ISSN
- 1615-4150
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📜 SIMILAR VOLUMES
## Abstract Well‐characterized resins of high purity are critical for effective solid phase peptide synthesis (SPPS). The quality of commercial (4‐methyl)benzhydrylamine‐resin (MBHA‐resin), used for the synthesis of peptide amides, is not consistent and residual ketone functionalities are frequentl
The use ofnucleophiles for the cleavage of an o-nitrobenzylester peptide-resin bond in order to afford peptide alkylesters and alkylamides has been studied. With this purpose, three short peptide sequences anchored to a Nbb-resin were used as models. Peptides were cleaved from the polymeric supports