𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Stereospecific synthesis of 4-carboxyphenylalanine and derivatives for use in Fmoc-based solid-phase peptide synthesis

✍ Scribed by Wei Wang; Nihal U. Obeyesekere; John S. McMurray


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
262 KB
Volume
37
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Convenient preparation of 4-(tetrazol-5-
✍ John S McMurray; Olga Khabashesku; James S Birtwistle; Wei Wang πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 101 KB

To create a novel amino acid incorporating both acidic and aromatic features, trimethyltin azide was used to synthesize l-4-(tetrazol-5-yl)-phenylalanine (Tpa) and the corresponding d,l racemate by [3+2] cycloadditition of azide to the nitrile group of corresponding 4-cyanophenylalanine analogs. N a

Peptide thioester preparation by Fmoc so
✍ Andrew B. Clippingdale; Colin J. Barrow; John D. Wade πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 135 KB πŸ‘ 2 views

Established methodology for the preparation of peptide thioesters requires the use of t-butoxycarbonyl chemistry owing to the lability of thioester linkers to the nucleophilic reagents used in Fmoc solid phase peptide synthesis. Both the greater ease of use and the broad applicability of the method

Protection of 3,4-dihydroxyphenylalanine
✍ Bi-Huang Hu; Phillip B Messersmith πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 110 KB

Cyclic ethyl orthoformate (Ceof) was utilized as a protecting group to protect the catechol hydroxyl groups of 3,4-dihydroxyphenylalanine (DOPA). This protecting group is stable to strong bases and nucleophiles, and can be removed eciently by 1 M trimethylsilyl bromide in triΒ―uoroacetic acid in the