𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Convenient synthesis of acetonide-protected 3,4-dihydroxyphenylalanine (DOPA) for Fmoc solid-phase peptide synthesis

✍ Scribed by Zhongqiang Liu; Bi-Huang Hu; Phillip B. Messersmith


Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
158 KB
Volume
49
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Protection of 3,4-dihydroxyphenylalanine
✍ Bi-Huang Hu; Phillip B Messersmith πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 110 KB

Cyclic ethyl orthoformate (Ceof) was utilized as a protecting group to protect the catechol hydroxyl groups of 3,4-dihydroxyphenylalanine (DOPA). This protecting group is stable to strong bases and nucleophiles, and can be removed eciently by 1 M trimethylsilyl bromide in triΒ―uoroacetic acid in the

Convenient preparation of 4-(tetrazol-5-
✍ John S McMurray; Olga Khabashesku; James S Birtwistle; Wei Wang πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 101 KB

To create a novel amino acid incorporating both acidic and aromatic features, trimethyltin azide was used to synthesize l-4-(tetrazol-5-yl)-phenylalanine (Tpa) and the corresponding d,l racemate by [3+2] cycloadditition of azide to the nitrile group of corresponding 4-cyanophenylalanine analogs. N a

An improved deblocking agent for direct
✍ Xianzhang Bu; Guiyang Xie; Chi Wang Law; Zhihong Guo πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 133 KB

To synthesize peptide thioesters directly on a solid support for use as substrate analogues for thioesterases in non-ribosomal peptide synthases, we modified a reagent compatible with Fmoc solid-phase peptide synthesis that efficiently removes the protecting group while keeping the thioester intact.

Alternative Strategies for the Fmoc Soli
✍ Eric A. Kitas; Reinhard Knorr; Arnold Trzeciak; Willi Bannwarth πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 German βš– 883 KB

A number of biologically relevant 04-phospho-~-tyrosine-containing peptides have been synthesized by either the global phosphorylation of the side-chain-unprotected L-tyrosine moiety in presynthesized resin-bound peptides or alternatively by the incorporation of suitably protected 04-phospho-~-tyros