Cyclic ethyl orthoformate (Ceof) was utilized as a protecting group to protect the catechol hydroxyl groups of 3,4-dihydroxyphenylalanine (DOPA). This protecting group is stable to strong bases and nucleophiles, and can be removed eciently by 1 M trimethylsilyl bromide in triΒ―uoroacetic acid in the
Convenient synthesis of acetonide-protected 3,4-dihydroxyphenylalanine (DOPA) for Fmoc solid-phase peptide synthesis
β Scribed by Zhongqiang Liu; Bi-Huang Hu; Phillip B. Messersmith
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 158 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
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