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Alternative Strategies for the Fmoc Solid-Phase Synthesis of O4-Phospho-L-tyrosine-Containing Peptides

✍ Scribed by Eric A. Kitas; Reinhard Knorr; Arnold Trzeciak; Willi Bannwarth

Publisher: John Wiley and Sons
Year: 1991
Tongue: German
Weight: 883 KB
Volume: 74
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19910740621

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✦ Synopsis

A number of biologically relevant 04-phospho-~-tyrosine-containing peptides have been synthesized by either the global phosphorylation of the side-chain-unprotected L-tyrosine moiety in presynthesized resin-bound peptides or alternatively by the incorporation of suitably protected 04-phospho-~-tyrosine building blocks in the continuous-flow method of Fmoc solid-phase peptide synthesis. Different phosphate-protecting groups have been applied.

1. Introduction.

-Protein phosphorylation is regarded as an important post-translational modification which regulates enzymic functions within cells [ 11 [2]. Phosphoryla-

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