𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of Multi-O4-phospho-L-tyrosine-Containing Peptides

✍ Scribed by Willi Bannwarth; Eric A. Kitas

Publisher
John Wiley and Sons
Year
1992
Tongue
German
Weight
449 KB
Volume
75
Category
Article
ISSN
0018-019X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Multi‐O^4^‐phospho‐L‐tyrosine‐containing peptides can be synthesized by the global as well as the buildingblock approach. Thus, we prepared by both strategies the triphosphorylated and the three regioisomeric diphosphorylated insulin‐receptor‐(1142–1153)‐dodecapeptide derivatives 7 and 4–6, respectively, of the parent Thr‐Arg‐Asp‐Ile‐Tyr‐Glu‐Thr‐Asp‐Tyr‐Tyr‐Arg‐Lys (3). These phosphorylated peptides are valuable tools to study the regioselectivity of dephosphorylation by phosphatases.

📜 SIMILAR VOLUMES

Synthesis of Sequential Polypeptides Con
Synthesis of Sequential Polypeptides Containing O-Phospho-L-Serine
✍ Hiroyuki Yamamoto; Arihiro Saitoh; Kousaku Ohkawa 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB

## Abstract The chemistry of phosphoserine [Ser(P)] containing peptides and polypeptides was extensively investigated to explore a new biomineralization material science. The selective cleavage of the __O__,__O′__‐diphenyl phospho‐protecting groups of Ser(PO~3~Ph~2~) was examined using hydrogenolys