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Small-sized HIV protease inhibitors containing allophenyinorstatine exhibit antiviral activities

✍ Scribed by Y. Kiso; T. Mimoto; R. Kato; T. Mitoguchi; S. Nakata; T. Kimura; J.W. Erickson; M.A. Ussery


Book ID
113259576
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
64 KB
Volume
30
Category
Article
ISSN
0166-3542

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KNI-577, a Potent Small-Sized HIV Protease Inhibitor Based on the Dipeptide Containing the Hydroxymethylcarbonyl Isostere as an Ideal Transition-State Mimic -[synthesis of the title compound (I), which exhibits potent antiviral activities, low cytotoxicity and good pharmacokinetic properties after i