𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Small-Molecule Allosteric Activators of Sirtuins

✍ Scribed by Sinclair, David A.; Guarente, Leonard

Book ID
121349484
Publisher
Annual Reviews
Year
2014
Tongue
English
Weight
744 KB
Volume
54
Category
Article
ISSN
0362-1642

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## Abstract Activation of the p53 tumour suppressor is predicted to have therapeutically beneficial effects. Many current anti‐cancer therapies activate the p53 response __via__ DNA damage. Non‐genotoxic activation of the p53 pathway would open the way to long‐term and possibly prophylactic treatme