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Pilot screening programme for small molecule activators of p53

โœ Scribed by Rachel G. Berkson; Jonathan J. Hollick; Nicholas J. Westwood; Julie A. Woods; David P. Lane; Sonia Lain

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
328 KB
Volume
115
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

Abstract

Activation of the p53 tumour suppressor is predicted to have therapeutically beneficial effects. Many current antiโ€cancer therapies activate the p53 response via DNA damage. Nonโ€genotoxic activation of the p53 pathway would open the way to longโ€term and possibly prophylactic treatments. We have established a simple protocol to screen small compound libraries for activators of p53โ€dependent transcription, and to select and characterise the most interesting hits, which include nonโ€genotoxic activators. These compounds or their derivatives are of potential clinical interest. This approach may also lead to the identification of novel p53โ€activating compound families and possibly to the description of novel molecular pathways regulating p53 activity. ยฉ 2005 Wileyโ€Liss, Inc.

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