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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

โœ Scribed by Howitz, Konrad T.; Bitterman, Kevin J.; Cohen, Haim Y.; Lamming, Dudley W.; Lavu, Siva; Wood, Jason G.; Zipkin, Robert E.; Chung, Phuong; Kisielewski, Anne; Zhang, Li-Li

Book ID
109891380
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
538 KB
Volume
425
Category
Article
ISSN
0028-0836

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## Abstract Mitochondrial DNA (mtDNA) mutations escalate with increasing age in higher organisms. However, it has so far been difficult to experimentally determine whether mtDNA mutation merely correlates with age or directly limits lifespan. A recent study shows that budding yeast can also lose fu