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SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines

โœ Scribed by Ji Kon Ryu; Woo Jin Lee; Kwang Hyuck Lee; Jin-Hyeok Hwang; Yong-Tae Kim; Yong Bum Yoon; Chung Yong Kim


Book ID
116333823
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
751 KB
Volume
237
Category
Article
ISSN
0304-3835

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## Abstract Remodeling of the chromatin template by inhibition of HDAC activities represents a potential transcriptional therapy for neoplastic disease. A number of HDAC inhibitors that modulate __in vitro__ cell growth and differentiation have been developed. We analyzed the effects of TSA, a spec