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Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells

โœ Scribed by Jirong Bai; Aram Demirjian; Jianhua Sui; Wayne Marasco; Mark P. Callery


Book ID
116293444
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
298 KB
Volume
348
Category
Article
ISSN
0006-291X

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Histone deacetylase inhibitor trichostat
โœ Yo-ichi Yamashita; Mitsuo Shimada; Norifumi Harimoto; Tatsuya Rikimaru; Ken Shir ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 212 KB ๐Ÿ‘ 1 views

## Abstract Remodeling of the chromatin template by inhibition of HDAC activities represents a potential transcriptional therapy for neoplastic disease. A number of HDAC inhibitors that modulate __in vitro__ cell growth and differentiation have been developed. We analyzed the effects of TSA, a spec