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A novel δ-lactam-based histone deacetylase inhibitor, KBH-A42, induces cell cycle arrest and apoptosis in colon cancer cells

✍ Scribed by Moo Rim Kang; Jong Soon Kang; Sang-Bae Han; Jang Hyun Kim; Dong-Myung Kim; Kiho Lee; Chang Woo Lee; Ki Hoon Lee; Chul Ho Lee; Gyoonhee Han; Jong Seong Kang; Hwan Mook Kim; Song-Kyu Park


Book ID
113488830
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
609 KB
Volume
78
Category
Article
ISSN
0006-2952

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## Abstract Remodeling of the chromatin template by inhibition of HDAC activities represents a potential transcriptional therapy for neoplastic disease. A number of HDAC inhibitors that modulate __in vitro__ cell growth and differentiation have been developed. We analyzed the effects of TSA, a spec