Atrasentan is an endothelin antagonist selective for the ET A receptor in development at Abbott Laboratories for the treatment of cardiovascular disease and cell proliferation disorders. A simple and sensitive chromatographic method for the determination of atrasentan in human plasma has been develo
Simultaneous determination of tacrine and 1-hydroxy-, 2-hydroxy-, and 4-hydroxytacrine in human plasma by high-performance liquid chromatography with fluorescence detection
β Scribed by David B. Haughey; Mary S. Collis; Patricia M. Klockowski; Colleen A. McNaney; Richard R. Brown; Paul H. Siedlik; Linda Balogh
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 423 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract A simple, specific and sensitive HPLC method has been developed for the determination of metoprolol in human plasma and urine. Separation of metoprolol and atenolol (internal standard) was achieved on an Ace C~18~ column (5βΞΌm, 250βmmΓ4.6βmm id) using fluorescence detection with Ξ»~ex~=2
in fasted and fed dogs were similar to those reported A nonradioisotopic method has been developed for previously for human and rat plasma (6). the determination of all-trans-farnesyl pyrophos-All-trans-farnesyl pyrophosphate (FPP), the immediphate (FPP), the common intermediate at the branch ate p