Simultaneous determination of acyclovir, ganciclovir, and (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine in human plasma using high-performance liquid chromatography

A simple and simultaneous determination

A simple and simultaneous determination of acyclovir and ganciclovir in human plasma by high-performance liquid chromatography

✍ Daisuke Teshima; Kaori Otsubo; Tsuneko Yoshida; Yoshinori Itoh; Ryozo Oishi 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 74 KB 👁 2 views

## Abstract A simple high‐performance liquid chromatographic method was developed for the simultaneous determination of the therapeutic levels of acyclovir and ganciclovir in human plasma. After precipitation of plasma proteins with 6% perchloric acid, acyclovir and ganciclovir were simultaneously