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Simultaneous assay of 3,4-dihydroxyphenylalanine, catecholamines and O-methylated metabolites in human plasma using high-performance liquid chromatography

โœ Scribed by Tadashi Ishimitsu; Shingo Hirose

Publisher
Elsevier Science
Year
1985
Weight
607 KB
Volume
337
Category
Article
ISSN
0378-4347

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Determination of m- and p-O-methylated p
Determination of m- and p-O-methylated products of l-3,4-dihydroxyphenylalanine using high-performance liquid chromatography and electrochemical detection
โœ Tadashi Ishimitsu; Shingo Hirose ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 589 KB

In a study of in vitro and in vivo metabolism of L-3,4dihydroxyphenylalanine (L-Dopa), two methods of high-performance liquid chromatography (HPLC) were used to separate the m-and p-O-methylated products. A reversed-phase column and an aqueous mobile phase by gradient elution were used; the elute w