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Simultaneous Automatic Determination of Catecholamines and Their 3-O-Methyl Metabolites in Rat Plasma by High-Performance Liquid Chromatography Using Peroxyoxalate Chemiluminescence Reaction

โœ Scribed by Makoto Tsunoda; Kazuko Takezawa; Tomofumi Santa; Kazuhiro Imai


Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
113 KB
Volume
269
Category
Article
ISSN
0003-2697

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A specific HPLC method for the simultaneous determination of YM928, a novel noncompetitive AMPA receptor antagonist, and its demethylated metabolite (YM-58875) in rat, dog and monkey plasma was developed and validated. The method utilized multiple-step liquid-liquid extraction followed by a reversed