Simple syntheses of malathion and malaoxon enantiomers, and isomalathion diastereoisomers: toxicity-configuration relationship

✍ Scribed by Połeć, Iwona; Cieślak, Ludwika; Śledziński, Bohdan; Ksycińska, Hanna

• Book ID: 101214840
• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 247 KB
• Volume: 53
• Category: Article
• ISSN: 1526-498X
• DOI: 10.1002/(sici)1096-9063(199806)53:2<165::aid-ps747>3.0.co;2-0

✦ Synopsis

Malathion enantiomers were synthesized by nucleophilic substitution of O,O-dimethyl dithiophosphoryl anion to diethyl (R)-or (S)-2-bromosuccinate. Malaoxon enantiomers were obtained from optically active malathions in thionoÈthiolo rearrangement with 65% Desmethylation of malathion HNO 3 . enantiomers by triethylamine, following the remethylation using methyl iodide gave isomalathion diastereomeric pairs. Physicochemical characteristics of the compounds obtained, and their inÑuence on rats and some species of arthropods, are presented.

1998 SCI (