Similarity study of serine proteases inhibitors
โ Scribed by Gleb D. Perekhodtsev
- Book ID
- 106468163
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 220 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1381-1991
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Thrombin and factor Xa (fXa) are the only serine proteases for which small, potent, selective, noncovalent inhibitors have been developed, which are ultimately intended as drug development candidates (in this case as anticoagulants). Noncovalent inhibitors may be more selective and chemically and me
Analogues of phenylalanine and lysine esters were synthesized, and their inhibitory power tested in vitro respectively on chyrnonypsin, trypsin and uroklnase. Electrophilic phosphonate analogues of N-acylated amino acids (e. g. structures 4 and 12) are potent inhibitors of serine proteasesl. These e
## Abstract For Abstract see ChemInform Abstract in Full Text.