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Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases

✍ Scribed by James C. Powers; Juliana L. Asgian; Oezlem Dogan Ekici; Karen Ellis James

Publisher
John Wiley and Sons
Year
2003
Weight
51 KB
Volume
34
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

For Abstract see ChemInform Abstract in Full Text.

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## BACKGROUND. Cathepsin B (CATB) and cathepsin L (CATL), which are cysteine proteases, urokinase-(UPA) and tissue-type plasminogen activator (TPA), both serine proteases, and their inhibitor type-1 (PAI-1) are believed to play an important role in colorectal carcinoma (CRC) invasion and metastasi