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The novel inhibitors of serine proteases

โœ Scribed by N. Hovhannisyan; Sh. Harutyunyan; A. Hovhannisyan; A. Hambardzumyan; M. Chitchyan; M. Melkumyan; G. Oganezova; N. Avetisyan


Book ID
106221809
Publisher
Springer
Year
2009
Tongue
English
Weight
308 KB
Volume
37
Category
Article
ISSN
0939-4451

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Thrombin and factor Xa (fXa) are the only serine proteases for which small, potent, selective, noncovalent inhibitors have been developed, which are ultimately intended as drug development candidates (in this case as anticoagulants). Noncovalent inhibitors may be more selective and chemically and me

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Analogues of phenylalanine and lysine esters were synthesized, and their inhibitory power tested in vitro respectively on chyrnonypsin, trypsin and uroklnase. Electrophilic phosphonate analogues of N-acylated amino acids (e. g. structures 4 and 12) are potent inhibitors of serine proteasesl. These e