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5151509 Gene encoding serine protease inhibitor


Book ID
103120112
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
75 KB
Volume
25
Category
Article
ISSN
0020-711X

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Small, noncovalent serine protease inhib
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Thrombin and factor Xa (fXa) are the only serine proteases for which small, potent, selective, noncovalent inhibitors have been developed, which are ultimately intended as drug development candidates (in this case as anticoagulants). Noncovalent inhibitors may be more selective and chemically and me

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We are interested in modeling enzymeแސinhibitor interactions with a view to improve the understanding of the biology of these processes. The present work focuses, therefore, on the research on enzymeแސinhibitor interactions using two highly homologous enzymes as our models: โค-factor XIIa and trypsin.