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ChemInform Abstract: Small, Noncovalent Serine Protease Inhibitors

✍ Scribed by Philip E. J. Sanderson

Publisher: John Wiley and Sons
Year: 2010
Weight: 23 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199921288

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Thrombin and factor Xa (fXa) are the only serine proteases for which small, potent, selective, noncovalent inhibitors have been developed, which are ultimately intended as drug development candidates (in this case as anticoagulants). Noncovalent inhibitors may be more selective and chemically and me

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