Significance of valine/leucine247 polymorphism of β2-glycoprotein I in antiphospholipid syndrome: Increased reactivity of anti–β2-glycoprotein I autoantibodies to the valine247 β2-glycoprotein I variant
✍ Scribed by Shinsuke Yasuda; Tatsuya Atsumi; Eiji Matsuura; Keiko Kaihara; Daisuke Yamamoto; Kenji Ichikawa; Takao Koike
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 142 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ## Objective Beta~2~‐glycoprotein I (β~2~GPI) is an important autoantigen in the antiphospholipid syndrome (APS). In vitro studies suggest that it may have multifaceted physiologic functions, since it displays both anticoagulant and procoagulant properties. We have previously reported
## Objective: To determine the frequency of mutations in the phospholipid binding domain of beta2-glycoprotein i (beta2gpi) in patients with systemic lupus erythematosus (sle) and/or antiphospholipid syndrome (aps), and to analyze the clinical correlations of such mutations with thromboembolic comp
Patients with the antiphospholipid syndrome (APS) have autoantibodies directed against epitopes on β 2 glycoprotein I (β 2 GPI). We describe herein the performance characteristics of standardized enzyme-linked immunosorbent assays (ELISAs) for antiβ 2 GPI of the three major immunoglobulin classes: I