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A role for the polymorphism at position 247 of the β2-glycoprotein I gene in the generation of anti–β2-glycoprotein I antibodies in the antiphospholipid syndrome

✍ Scribed by Naoto Hirose; Roxanne Williams; Alan R. Alberts; Richard A. Furie; Elliot K. Chartash; Rita I. Jain; Cristina Sison; Robert G. Lahita; Joan T. Merrill; Elena Cucurull; Azzudin E. Gharavi; Lisa R. Sammaritano; Jane E. Salmon; Shiori Hashimoto; Tetsuji Sawada; Charles C. Chu; Peter K. Gregersen; Nicholas Chiorazzi


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
185 KB
Volume
42
Category
Article
ISSN
0004-3591

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We describe two patients with the catastrophic antiphospholipid syndrome associated with elevation of ␤ 2glycoprotein I antibodies and fulminant thrombotic diatheses. Both patients were treated with therapeutic plasma exchange (TPE), which resulted in a marked decrease in antibody titer accompanied