Primary antiphospholipid antibody syndrome with mutations in the phospholipid binding domain of β2-glycoprotein I
✍ Scribed by Francisca C. Gushiken; Frank C. Arnett; Perumal Thiagarajan
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 257 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0361-8609
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## Abstract ## Objective Pathogenic antiphospholipid antibodies (aPL) bind the self antigen N‐terminal domain (domain I) of β~2~‐glycoprotein I (β~2~GPI), with residues G40–R43 being important. However, peptides homologous to other regions of domain I have also been shown to bind aPL. Furthermore,
Patients with the antiphospholipid syndrome (APS) have autoantibodies directed against epitopes on β 2 glycoprotein I (β 2 GPI). We describe herein the performance characteristics of standardized enzyme-linked immunosorbent assays (ELISAs) for antiβ 2 GPI of the three major immunoglobulin classes: I