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Beta2-glycoprotein I binds thrombin via exosite I and exosite II: Anti–β2-glycoprotein I antibodies potentiate the inhibitory effect of β2-glycoprotein I on thrombin-mediated factor XIa generation

✍ Scribed by Soheila Rahgozar; Qiuxia Yang; Bill Giannakopoulos; Xiaokai Yan; Spiros Miyakis; Steven A. Krilis


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
139 KB
Volume
56
Category
Article
ISSN
0004-3591

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Beta2-glycoprotein I protects thrombin f
✍ Soheila Rahgozar; Bill Giannakopoulos; Xiaokai Yan; Jiewei Wei; Jian Cheng Qi; R 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 261 KB

## Abstract ## Objective Beta~2~‐glycoprotein I (β~2~GPI) is an important autoantigen in the antiphospholipid syndrome (APS). In vitro studies suggest that it may have multifaceted physiologic functions, since it displays both anticoagulant and procoagulant properties. We have previously reported