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Should 6-thioguanine nucleotides Be monitored in patients with inflammatory bowel disease treated by azathioprin?

✍ Scribed by Arnaud Bourreille; Marie Doubremelle; Catherine Ganiere; Jean-Paul Galmiche

Book ID: 119427832
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 178 KB
Volume: 124
Category: Article
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(03)80974-5

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## Background: 6-thioguanine nucleotides (6-tgn) are active metabolites of azathioprine (aza) and 6-mercaptopurine (6mp). higher remission rates have been observed in patients with higher 6-tgn levels. however, many physicians prescribe aza/6mp using milligrams per kilogram (mg/kg) dosing regimens