Monitoring 6-thioguanine nucleotide concentrations in Japanese children and adolescents with inflammatory bowel disease
β Scribed by Yoshikazu Ohtsuka; Katsuhiro Arai; Yo Aoyagi; Tohru Fujii; Yoko Yamakawa; Kiyotaka Ohtani; Tamaki Ikuse; Yosuke Baba; Eisuke Inage; Takahiro Kudo; Ryuyo Suzuki; Satoru Nagata; Toshiaki Shimizu
- Book ID
- 108953784
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 233 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0815-9319
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π SIMILAR VOLUMES
## Background: 6-thioguanine nucleotides (6-tgn) are active metabolites of azathioprine (aza) and 6-mercaptopurine (6mp). higher remission rates have been observed in patients with higher 6-tgn levels. however, many physicians prescribe aza/6mp using milligrams per kilogram (mg/kg) dosing regimens
Background: Thiopurine drugs are widely used in the treatment of inflammatory bowel disease (IBD). The polymorphic enzyme thiopurine S-methyltransferase (TPMT) is of importance for thiopurine metabolism and adverse events occurrence. The role of other thiopurine-metabolizing enzymes is less well kno