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Impact of Thiopurine Methyltransferase Activity and 6-Thioguanine Nucleotide Concentrations in Patients with Chronic Inflammatory Diseases

✍ Scribed by JÖRG SCHEDEL; ANDREA GÖDDE; EKKEHARD SCHÜTZ; TIM A. BONGARTZ; BERNHARD LANG; JÜRGEN SCHÖLMERICH; ULF MÜLLER-LADNER

Book ID: 111479490
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 240 KB
Volume: 1069
Category: Article
ISSN: 0890-6564
DOI: 10.1196/annals.1351.048

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Background: Thiopurine drugs are widely used in the treatment of inflammatory bowel disease (IBD). The polymorphic enzyme thiopurine S-methyltransferase (TPMT) is of importance for thiopurine metabolism and adverse events occurrence. The role of other thiopurine-metabolizing enzymes is less well kno

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